Everolimus and Voriconazole: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Everolimus and Voriconazole unless specifically directed by your doctor.
How Everolimus interacts with Voriconazole
Voriconazole strongly inhibits CYP3A4 metabolism of everolimus, increasing everolimus AUC up to 7-fold with major risk of myelosuppression and stomatitis.
What you should do
Avoid the combination; if azole therapy needed in transplant or oncology patient, reduce everolimus by approximately 75% and monitor trough levels closely.
Key facts
Severity
Major — avoid combination
Mechanism
Voriconazole strongly inhibits CYP3A4 metabolism of everolimus, increasing everolimus AUC up to 7-fold with major risk o...
Action
Avoid the combination; if azole therapy needed in transplant or oncology patient, reduce everolimus by approximately 75%...
Frequently asked questions
Can I take Everolimus and Voriconazole together?
No — this combination should generally be avoided. Avoid the combination; if azole therapy needed in transplant or oncology patient, reduce everolimus by approximately 75% and monitor trough levels closely.
What is the severity of this interaction?
The interaction between Everolimus and Voriconazole is classified as Major — avoid combination. Voriconazole strongly inhibits CYP3A4 metabolism of everolimus, increasing everolimus AUC up to 7-fold with major risk of myelosuppression and stomatitis.
What should I do if I'm prescribed both?
Avoid the combination; if azole therapy needed in transplant or oncology patient, reduce everolimus by approximately 75% and monitor trough levels closely. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.