Fluoxetine and Linezolid: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Fluoxetine and Linezolid unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Fluoxetine interacts with Linezolid

Linezolid is a reversible MAO inhibitor that combined with SSRI-mediated serotonin reuptake inhibition can precipitate serotonin syndrome with hyperthermia, clonus and autonomic instability.

What you should do

Avoid combination; allow at least a 5-week washout after fluoxetine before starting linezolid, or use an alternative antibiotic.

Key facts

Severity

Major — avoid combination

Mechanism

Linezolid is a reversible MAO inhibitor that combined with SSRI-mediated serotonin reuptake inhibition can precipitate s...

Action

Avoid combination; allow at least a 5-week washout after fluoxetine before starting linezolid, or use an alternative ant...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Fluoxetine and Linezolid together?

No — this combination should generally be avoided. Avoid combination; allow at least a 5-week washout after fluoxetine before starting linezolid, or use an alternative antibiotic.

What is the severity of this interaction?

The interaction between Fluoxetine and Linezolid is classified as Major — avoid combination. Linezolid is a reversible MAO inhibitor that combined with SSRI-mediated serotonin reuptake inhibition can precipitate serotonin syndrome with hyperthermia, clonus and autonomic instability.

What should I do if I'm prescribed both?

Avoid combination; allow at least a 5-week washout after fluoxetine before starting linezolid, or use an alternative antibiotic. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.