Fluticasone and Ritonavir: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Fluticasone and Ritonavir unless specifically directed by your doctor.
How Fluticasone interacts with Ritonavir
Ritonavir strongly inhibits CYP3A4, the main clearance pathway for fluticasone. Systemic corticosteroid exposure can increase markedly, causing Cushing's syndrome and adrenal suppression.
What you should do
Avoid inhaled or intranasal fluticasone with ritonavir when possible. Use an alternative corticosteroid strategy and monitor for adrenal suppression if exposure has occurred.
Key facts
Severity
Major — avoid combination
Mechanism
Ritonavir strongly inhibits CYP3A4, the main clearance pathway for fluticasone. Systemic corticosteroid exposure can inc...
Action
Avoid inhaled or intranasal fluticasone with ritonavir when possible. Use an alternative corticosteroid strategy and mon...
Frequently asked questions
Can I take Fluticasone and Ritonavir together?
No — this combination should generally be avoided. Avoid inhaled or intranasal fluticasone with ritonavir when possible. Use an alternative corticosteroid strategy and monitor for adrenal suppression if exposure has occurred.
What is the severity of this interaction?
The interaction between Fluticasone and Ritonavir is classified as Major — avoid combination. Ritonavir strongly inhibits CYP3A4, the main clearance pathway for fluticasone. Systemic corticosteroid exposure can increase markedly, causing Cushing's syndrome and adrenal suppression.
What should I do if I'm prescribed both?
Avoid inhaled or intranasal fluticasone with ritonavir when possible. Use an alternative corticosteroid strategy and monitor for adrenal suppression if exposure has occurred. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.