Gemfibrozil and Statin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Gemfibrozil and Statin unless specifically directed by your doctor.
How Gemfibrozil interacts with Statin
Gemfibrozil inhibits OATP1B1 hepatic uptake and CYP-independent glucuronidation of statins, raising plasma concentrations and substantially increasing rhabdomyolysis risk.
What you should do
Combination is contraindicated. If a fibrate is needed for severe hypertriglyceridaemia, use fenofibrate, which has a much lower interaction risk.
Key facts
Severity
Major — avoid combination
Mechanism
Gemfibrozil inhibits OATP1B1 hepatic uptake and CYP-independent glucuronidation of statins, raising plasma concentration...
Action
Combination is contraindicated. If a fibrate is needed for severe hypertriglyceridaemia, use fenofibrate, which has a mu...
Frequently asked questions
Can I take Gemfibrozil and Statin together?
No — this combination should generally be avoided. Combination is contraindicated. If a fibrate is needed for severe hypertriglyceridaemia, use fenofibrate, which has a much lower interaction risk.
What is the severity of this interaction?
The interaction between Gemfibrozil and Statin is classified as Major — avoid combination. Gemfibrozil inhibits OATP1B1 hepatic uptake and CYP-independent glucuronidation of statins, raising plasma concentrations and substantially increasing rhabdomyolysis risk.
What should I do if I'm prescribed both?
Combination is contraindicated. If a fibrate is needed for severe hypertriglyceridaemia, use fenofibrate, which has a much lower interaction risk. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.