Midazolam and Voriconazole: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Midazolam and Voriconazole unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Midazolam interacts with Voriconazole

Voriconazole strongly inhibits CYP3A4 metabolism of midazolam, increasing benzodiazepine exposure. This can cause prolonged sedation and respiratory depression.

What you should do

Avoid oral midazolam with voriconazole. If parenteral midazolam is necessary, use reduced doses with close cardiorespiratory monitoring.

Key facts

Severity

Major — avoid combination

Mechanism

Voriconazole strongly inhibits CYP3A4 metabolism of midazolam, increasing benzodiazepine exposure. This can cause prolon...

Action

Avoid oral midazolam with voriconazole. If parenteral midazolam is necessary, use reduced doses with close cardiorespira...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Midazolam and Voriconazole together?

No — this combination should generally be avoided. Avoid oral midazolam with voriconazole. If parenteral midazolam is necessary, use reduced doses with close cardiorespiratory monitoring.

What is the severity of this interaction?

The interaction between Midazolam and Voriconazole is classified as Major — avoid combination. Voriconazole strongly inhibits CYP3A4 metabolism of midazolam, increasing benzodiazepine exposure. This can cause prolonged sedation and respiratory depression.

What should I do if I'm prescribed both?

Avoid oral midazolam with voriconazole. If parenteral midazolam is necessary, use reduced doses with close cardiorespiratory monitoring. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.