Moclobemide and Pseudoephedrine: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Moclobemide and Pseudoephedrine unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Moclobemide interacts with Pseudoephedrine

MAO-A inhibition by moclobemide prevents breakdown of noradrenaline released by indirect sympathomimetics, causing hypertensive crisis.

What you should do

Avoid all indirect sympathomimetics (pseudoephedrine, phenylephrine) during and for 2 weeks after moclobemide therapy.

Key facts

Severity

Major — avoid combination

Mechanism

MAO-A inhibition by moclobemide prevents breakdown of noradrenaline released by indirect sympathomimetics, causing hyper...

Action

Avoid all indirect sympathomimetics (pseudoephedrine, phenylephrine) during and for 2 weeks after moclobemide therapy.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Moclobemide and Pseudoephedrine together?

No — this combination should generally be avoided. Avoid all indirect sympathomimetics (pseudoephedrine, phenylephrine) during and for 2 weeks after moclobemide therapy.

What is the severity of this interaction?

The interaction between Moclobemide and Pseudoephedrine is classified as Major — avoid combination. MAO-A inhibition by moclobemide prevents breakdown of noradrenaline released by indirect sympathomimetics, causing hypertensive crisis.

What should I do if I'm prescribed both?

Avoid all indirect sympathomimetics (pseudoephedrine, phenylephrine) during and for 2 weeks after moclobemide therapy. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.