Moclobemide and Venlafaxine: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Moclobemide and Venlafaxine unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Moclobemide interacts with Venlafaxine

Combining the MAO-A inhibitor moclobemide with the serotonin-noradrenaline reuptake inhibitor venlafaxine produces excessive synaptic serotonin and risk of serotonin syndrome.

What you should do

Combination is contraindicated; allow at least a 7-day washout after stopping venlafaxine before starting moclobemide, and 24 hours after moclobemide before starting venlafaxine.

Key facts

Severity

Major — avoid combination

Mechanism

Combining the MAO-A inhibitor moclobemide with the serotonin-noradrenaline reuptake inhibitor venlafaxine produces exces...

Action

Combination is contraindicated; allow at least a 7-day washout after stopping venlafaxine before starting moclobemide, a...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Moclobemide and Venlafaxine together?

No — this combination should generally be avoided. Combination is contraindicated; allow at least a 7-day washout after stopping venlafaxine before starting moclobemide, and 24 hours after moclobemide before starting venlafaxine.

What is the severity of this interaction?

The interaction between Moclobemide and Venlafaxine is classified as Major — avoid combination. Combining the MAO-A inhibitor moclobemide with the serotonin-noradrenaline reuptake inhibitor venlafaxine produces excessive synaptic serotonin and risk of serotonin syndrome.

What should I do if I'm prescribed both?

Combination is contraindicated; allow at least a 7-day washout after stopping venlafaxine before starting moclobemide, and 24 hours after moclobemide before starting venlafaxine. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.