Moclobemide and Tramadol: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Moclobemide and Tramadol unless specifically directed by your doctor.
How Moclobemide interacts with Tramadol
Tramadol is a serotonin and noradrenaline reuptake inhibitor; combined with the MAO-A inhibitor moclobemide, it can precipitate serotonin syndrome and lower seizure threshold.
What you should do
Avoid the combination; choose codeine or morphine as alternative analgesics and allow a 2-week washout before switching.
Key facts
Severity
Major — avoid combination
Mechanism
Tramadol is a serotonin and noradrenaline reuptake inhibitor; combined with the MAO-A inhibitor moclobemide, it can prec...
Action
Avoid the combination; choose codeine or morphine as alternative analgesics and allow a 2-week washout before switching.
Frequently asked questions
Can I take Moclobemide and Tramadol together?
No — this combination should generally be avoided. Avoid the combination; choose codeine or morphine as alternative analgesics and allow a 2-week washout before switching.
What is the severity of this interaction?
The interaction between Moclobemide and Tramadol is classified as Major — avoid combination. Tramadol is a serotonin and noradrenaline reuptake inhibitor; combined with the MAO-A inhibitor moclobemide, it can precipitate serotonin syndrome and lower seizure threshold.
What should I do if I'm prescribed both?
Avoid the combination; choose codeine or morphine as alternative analgesics and allow a 2-week washout before switching. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.