Rasagiline and Venlafaxine: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Rasagiline and Venlafaxine unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Rasagiline interacts with Venlafaxine

Rasagiline selectively inhibits MAO-B but loses selectivity at higher doses; combined with venlafaxine's SNRI action can precipitate serotonin syndrome.

What you should do

Avoid combination per manufacturer guidance. Allow 14-day washout between drugs. Monitor for hyperthermia, agitation, and neuromuscular signs if used.

Key facts

Severity

Major — avoid combination

Mechanism

Rasagiline selectively inhibits MAO-B but loses selectivity at higher doses; combined with venlafaxine's SNRI action can...

Action

Avoid combination per manufacturer guidance. Allow 14-day washout between drugs. Monitor for hyperthermia, agitation, an...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Rasagiline and Venlafaxine together?

No — this combination should generally be avoided. Avoid combination per manufacturer guidance. Allow 14-day washout between drugs. Monitor for hyperthermia, agitation, and neuromuscular signs if used.

What is the severity of this interaction?

The interaction between Rasagiline and Venlafaxine is classified as Major — avoid combination. Rasagiline selectively inhibits MAO-B but loses selectivity at higher doses; combined with venlafaxine's SNRI action can precipitate serotonin syndrome.

What should I do if I'm prescribed both?

Avoid combination per manufacturer guidance. Allow 14-day washout between drugs. Monitor for hyperthermia, agitation, and neuromuscular signs if used. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.