Mycophenolate and Rifampicin: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Mycophenolate and Rifampicin unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Mycophenolate interacts with Rifampicin

Rifampicin induces UGT enzymes and disrupts enterohepatic recirculation of mycophenolic acid, significantly reducing exposure and risking transplant rejection.

What you should do

Avoid combination where possible. If required, monitor mycophenolic acid levels and consider dose escalation.

Key facts

Severity

Major — avoid combination

Mechanism

Rifampicin induces UGT enzymes and disrupts enterohepatic recirculation of mycophenolic acid, significantly reducing exp...

Action

Avoid combination where possible. If required, monitor mycophenolic acid levels and consider dose escalation.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Mycophenolate and Rifampicin together?

No — this combination should generally be avoided. Avoid combination where possible. If required, monitor mycophenolic acid levels and consider dose escalation.

What is the severity of this interaction?

The interaction between Mycophenolate and Rifampicin is classified as Major — avoid combination. Rifampicin induces UGT enzymes and disrupts enterohepatic recirculation of mycophenolic acid, significantly reducing exposure and risking transplant rejection.

What should I do if I'm prescribed both?

Avoid combination where possible. If required, monitor mycophenolic acid levels and consider dose escalation. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.