Mycophenolate Mofetil and Rifampicin: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Mycophenolate Mofetil and Rifampicin unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Mycophenolate Mofetil interacts with Rifampicin

Rifampicin induces UGT enzymes responsible for mycophenolic acid glucuronidation and enterohepatic recirculation, substantially lowering active drug exposure.

What you should do

Avoid the combination in transplant recipients; if rifampicin is essential, monitor mycophenolic acid levels and graft function and adjust the dose.

Key facts

Severity

Major — avoid combination

Mechanism

Rifampicin induces UGT enzymes responsible for mycophenolic acid glucuronidation and enterohepatic recirculation, substa...

Action

Avoid the combination in transplant recipients; if rifampicin is essential, monitor mycophenolic acid levels and graft f...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Mycophenolate Mofetil and Rifampicin together?

No — this combination should generally be avoided. Avoid the combination in transplant recipients; if rifampicin is essential, monitor mycophenolic acid levels and graft function and adjust the dose.

What is the severity of this interaction?

The interaction between Mycophenolate Mofetil and Rifampicin is classified as Major — avoid combination. Rifampicin induces UGT enzymes responsible for mycophenolic acid glucuronidation and enterohepatic recirculation, substantially lowering active drug exposure.

What should I do if I'm prescribed both?

Avoid the combination in transplant recipients; if rifampicin is essential, monitor mycophenolic acid levels and graft function and adjust the dose. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.