Ranolazine and Verapamil: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ranolazine and Verapamil unless specifically directed by your doctor.
How Ranolazine interacts with Verapamil
Verapamil inhibits CYP3A4 and P-glycoprotein, increasing ranolazine concentrations and risk of QT prolongation, torsades de pointes, and dose-dependent toxicity.
What you should do
Limit ranolazine dose to maximum 500 mg twice daily when used with verapamil. Monitor ECG for QT prolongation.
Key facts
Severity
Major — avoid combination
Mechanism
Verapamil inhibits CYP3A4 and P-glycoprotein, increasing ranolazine concentrations and risk of QT prolongation, torsades...
Action
Limit ranolazine dose to maximum 500 mg twice daily when used with verapamil. Monitor ECG for QT prolongation.
Frequently asked questions
Can I take Ranolazine and Verapamil together?
No — this combination should generally be avoided. Limit ranolazine dose to maximum 500 mg twice daily when used with verapamil. Monitor ECG for QT prolongation.
What is the severity of this interaction?
The interaction between Ranolazine and Verapamil is classified as Major — avoid combination. Verapamil inhibits CYP3A4 and P-glycoprotein, increasing ranolazine concentrations and risk of QT prolongation, torsades de pointes, and dose-dependent toxicity.
What should I do if I'm prescribed both?
Limit ranolazine dose to maximum 500 mg twice daily when used with verapamil. Monitor ECG for QT prolongation. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.