Selegiline and Sumatriptan: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Selegiline and Sumatriptan unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Selegiline interacts with Sumatriptan

Selegiline (MAO-B inhibitor; loses selectivity at higher doses) combined with the serotonergic triptan increases the risk of serotonin syndrome and hypertensive reactions.

What you should do

Avoid sumatriptan within 2 weeks of stopping selegiline. Use non-triptan migraine treatment such as naproxen or paracetamol-based therapy.

Key facts

Severity

Major — avoid combination

Mechanism

Selegiline (MAO-B inhibitor; loses selectivity at higher doses) combined with the serotonergic triptan increases the ris...

Action

Avoid sumatriptan within 2 weeks of stopping selegiline. Use non-triptan migraine treatment such as naproxen or paraceta...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Selegiline and Sumatriptan together?

No — this combination should generally be avoided. Avoid sumatriptan within 2 weeks of stopping selegiline. Use non-triptan migraine treatment such as naproxen or paracetamol-based therapy.

What is the severity of this interaction?

The interaction between Selegiline and Sumatriptan is classified as Major — avoid combination. Selegiline (MAO-B inhibitor; loses selectivity at higher doses) combined with the serotonergic triptan increases the risk of serotonin syndrome and hypertensive reactions.

What should I do if I'm prescribed both?

Avoid sumatriptan within 2 weeks of stopping selegiline. Use non-triptan migraine treatment such as naproxen or paracetamol-based therapy. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.