Amphotericin B and Ciclosporin: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Amphotericin B and Ciclosporin unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Amphotericin B interacts with Ciclosporin

Both agents cause dose-dependent nephrotoxicity through afferent arteriolar vasoconstriction and direct tubular injury, producing additive renal damage.

What you should do

Avoid combination where possible; use liposomal amphotericin if antifungal therapy is essential, ensure aggressive hydration, and monitor renal function daily.

Key facts

Severity

Major — avoid combination

Mechanism

Both agents cause dose-dependent nephrotoxicity through afferent arteriolar vasoconstriction and direct tubular injury, ...

Action

Avoid combination where possible; use liposomal amphotericin if antifungal therapy is essential, ensure aggressive hydra...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Amphotericin B and Ciclosporin together?

No — this combination should generally be avoided. Avoid combination where possible; use liposomal amphotericin if antifungal therapy is essential, ensure aggressive hydration, and monitor renal function daily.

What is the severity of this interaction?

The interaction between Amphotericin B and Ciclosporin is classified as Major — avoid combination. Both agents cause dose-dependent nephrotoxicity through afferent arteriolar vasoconstriction and direct tubular injury, producing additive renal damage.

What should I do if I'm prescribed both?

Avoid combination where possible; use liposomal amphotericin if antifungal therapy is essential, ensure aggressive hydration, and monitor renal function daily. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.