Ciclosporin and Pravastatin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ciclosporin and Pravastatin unless specifically directed by your doctor.
How Ciclosporin interacts with Pravastatin
Ciclosporin inhibits OATP1B1-mediated hepatic uptake of pravastatin, increasing statin plasma concentrations roughly 5-fold and the risk of myopathy.
What you should do
Limit pravastatin to 20 mg daily in patients on ciclosporin. Educate patients to report muscle pain promptly and check CK if symptomatic.
Key facts
Severity
Major — avoid combination
Mechanism
Ciclosporin inhibits OATP1B1-mediated hepatic uptake of pravastatin, increasing statin plasma concentrations roughly 5-f...
Action
Limit pravastatin to 20 mg daily in patients on ciclosporin. Educate patients to report muscle pain promptly and check C...
Frequently asked questions
Can I take Ciclosporin and Pravastatin together?
No — this combination should generally be avoided. Limit pravastatin to 20 mg daily in patients on ciclosporin. Educate patients to report muscle pain promptly and check CK if symptomatic.
What is the severity of this interaction?
The interaction between Ciclosporin and Pravastatin is classified as Major — avoid combination. Ciclosporin inhibits OATP1B1-mediated hepatic uptake of pravastatin, increasing statin plasma concentrations roughly 5-fold and the risk of myopathy.
What should I do if I'm prescribed both?
Limit pravastatin to 20 mg daily in patients on ciclosporin. Educate patients to report muscle pain promptly and check CK if symptomatic. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.