Atorvastatin and Ciclosporin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Atorvastatin and Ciclosporin unless specifically directed by your doctor.
How Atorvastatin interacts with Ciclosporin
Ciclosporin inhibits OATP1B1 and CYP3A4, markedly increasing atorvastatin plasma levels and risk of myopathy/rhabdomyolysis.
What you should do
Limit atorvastatin to maximum 10 mg daily when combined with ciclosporin and monitor for muscle symptoms and creatine kinase.
Key facts
Severity
Major — avoid combination
Mechanism
Ciclosporin inhibits OATP1B1 and CYP3A4, markedly increasing atorvastatin plasma levels and risk of myopathy/rhabdomyoly...
Action
Limit atorvastatin to maximum 10 mg daily when combined with ciclosporin and monitor for muscle symptoms and creatine ki...
Frequently asked questions
Can I take Atorvastatin and Ciclosporin together?
No — this combination should generally be avoided. Limit atorvastatin to maximum 10 mg daily when combined with ciclosporin and monitor for muscle symptoms and creatine kinase.
What is the severity of this interaction?
The interaction between Atorvastatin and Ciclosporin is classified as Major — avoid combination. Ciclosporin inhibits OATP1B1 and CYP3A4, markedly increasing atorvastatin plasma levels and risk of myopathy/rhabdomyolysis.
What should I do if I'm prescribed both?
Limit atorvastatin to maximum 10 mg daily when combined with ciclosporin and monitor for muscle symptoms and creatine kinase. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.