Carvedilol and Verapamil: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Carvedilol and Verapamil unless specifically directed by your doctor.
How Carvedilol interacts with Verapamil
Both agents have negative inotropic, chronotropic, and dromotropic effects on the AV node; verapamil also inhibits CYP2D6-mediated carvedilol metabolism, intensifying beta-blockade.
What you should do
Avoid combination, particularly in patients with reduced ejection fraction or conduction disease. If used, monitor heart rate, blood pressure, and signs of heart failure closely.
Key facts
Severity
Major — avoid combination
Mechanism
Both agents have negative inotropic, chronotropic, and dromotropic effects on the AV node; verapamil also inhibits CYP2D...
Action
Avoid combination, particularly in patients with reduced ejection fraction or conduction disease. If used, monitor heart...
Frequently asked questions
Can I take Carvedilol and Verapamil together?
No — this combination should generally be avoided. Avoid combination, particularly in patients with reduced ejection fraction or conduction disease. If used, monitor heart rate, blood pressure, and signs of heart failure closely.
What is the severity of this interaction?
The interaction between Carvedilol and Verapamil is classified as Major — avoid combination. Both agents have negative inotropic, chronotropic, and dromotropic effects on the AV node; verapamil also inhibits CYP2D6-mediated carvedilol metabolism, intensifying beta-blockade.
What should I do if I'm prescribed both?
Avoid combination, particularly in patients with reduced ejection fraction or conduction disease. If used, monitor heart rate, blood pressure, and signs of heart failure closely. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.