Ciclosporin and Colchicine: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Ciclosporin and Colchicine unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Ciclosporin interacts with Colchicine

Ciclosporin inhibits P-glycoprotein and CYP3A4, markedly increasing colchicine exposure and risk of myopathy, neuropathy, and bone marrow toxicity.

What you should do

Avoid the combination, especially in renal or hepatic impairment. If essential, use specialist dosing advice and monitor for colchicine toxicity.

Key facts

Severity

Major — avoid combination

Mechanism

Ciclosporin inhibits P-glycoprotein and CYP3A4, markedly increasing colchicine exposure and risk of myopathy, neuropathy...

Action

Avoid the combination, especially in renal or hepatic impairment. If essential, use specialist dosing advice and monitor...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Ciclosporin and Colchicine together?

No — this combination should generally be avoided. Avoid the combination, especially in renal or hepatic impairment. If essential, use specialist dosing advice and monitor for colchicine toxicity.

What is the severity of this interaction?

The interaction between Ciclosporin and Colchicine is classified as Major — avoid combination. Ciclosporin inhibits P-glycoprotein and CYP3A4, markedly increasing colchicine exposure and risk of myopathy, neuropathy, and bone marrow toxicity.

What should I do if I'm prescribed both?

Avoid the combination, especially in renal or hepatic impairment. If essential, use specialist dosing advice and monitor for colchicine toxicity. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.