Citalopram and Omeprazole: Drug Interaction Guide
Quick answer: This combination requires caution. Citalopram and Omeprazole can be used together with adjustments and monitoring.
How Citalopram interacts with Omeprazole
Omeprazole inhibits CYP2C19, reducing citalopram clearance and increasing plasma concentrations, which raises the risk of dose-dependent QT prolongation.
What you should do
Limit citalopram to a maximum of 20 mg daily (10 mg in elderly or hepatic impairment) when combined with omeprazole; consider pantoprazole as a less interacting alternative.
Key facts
Severity
Moderate — caution required
Mechanism
Omeprazole inhibits CYP2C19, reducing citalopram clearance and increasing plasma concentrations, which raises the risk o...
Action
Limit citalopram to a maximum of 20 mg daily (10 mg in elderly or hepatic impairment) when combined with omeprazole; con...
Frequently asked questions
Can I take Citalopram and Omeprazole together?
With caution. Limit citalopram to a maximum of 20 mg daily (10 mg in elderly or hepatic impairment) when combined with omeprazole; consider pantoprazole as a less interacting alternative.
What is the severity of this interaction?
The interaction between Citalopram and Omeprazole is classified as Moderate — caution required. Omeprazole inhibits CYP2C19, reducing citalopram clearance and increasing plasma concentrations, which raises the risk of dose-dependent QT prolongation.
What should I do if I'm prescribed both?
Limit citalopram to a maximum of 20 mg daily (10 mg in elderly or hepatic impairment) when combined with omeprazole; consider pantoprazole as a less interacting alternative. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.