Clarithromycin and Everolimus: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Clarithromycin and Everolimus unless specifically directed by your doctor.
How Clarithromycin interacts with Everolimus
Clarithromycin strongly inhibits CYP3A4 and P-glycoprotein, markedly increasing everolimus exposure and the risk of serious toxicity.
What you should do
Avoid the combination and use an alternative antimicrobial. If unavoidable under specialist care, interrupt or substantially reduce everolimus and monitor concentrations and toxicity.
Key facts
Severity
Major — avoid combination
Mechanism
Clarithromycin strongly inhibits CYP3A4 and P-glycoprotein, markedly increasing everolimus exposure and the risk of seri...
Action
Avoid the combination and use an alternative antimicrobial. If unavoidable under specialist care, interrupt or substanti...
Frequently asked questions
Can I take Clarithromycin and Everolimus together?
No — this combination should generally be avoided. Avoid the combination and use an alternative antimicrobial. If unavoidable under specialist care, interrupt or substantially reduce everolimus and monitor concentrations and toxicity.
What is the severity of this interaction?
The interaction between Clarithromycin and Everolimus is classified as Major — avoid combination. Clarithromycin strongly inhibits CYP3A4 and P-glycoprotein, markedly increasing everolimus exposure and the risk of serious toxicity.
What should I do if I'm prescribed both?
Avoid the combination and use an alternative antimicrobial. If unavoidable under specialist care, interrupt or substantially reduce everolimus and monitor concentrations and toxicity. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.