Everolimus and Verapamil: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Everolimus and Verapamil unless specifically directed by your doctor.
How Everolimus interacts with Verapamil
Verapamil inhibits CYP3A4 and P-glycoprotein, increasing everolimus exposure and risk of toxicity including stomatitis, pneumonitis and myelosuppression.
What you should do
Avoid combination if possible; if required, reduce everolimus dose and monitor trough concentrations and adverse effects closely.
Key facts
Severity
Major — avoid combination
Mechanism
Verapamil inhibits CYP3A4 and P-glycoprotein, increasing everolimus exposure and risk of toxicity including stomatitis, ...
Action
Avoid combination if possible; if required, reduce everolimus dose and monitor trough concentrations and adverse effects...
Frequently asked questions
Can I take Everolimus and Verapamil together?
No — this combination should generally be avoided. Avoid combination if possible; if required, reduce everolimus dose and monitor trough concentrations and adverse effects closely.
What is the severity of this interaction?
The interaction between Everolimus and Verapamil is classified as Major — avoid combination. Verapamil inhibits CYP3A4 and P-glycoprotein, increasing everolimus exposure and risk of toxicity including stomatitis, pneumonitis and myelosuppression.
What should I do if I'm prescribed both?
Avoid combination if possible; if required, reduce everolimus dose and monitor trough concentrations and adverse effects closely. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.