Colchicine and Verapamil: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Colchicine and Verapamil unless specifically directed by your doctor.
How Colchicine interacts with Verapamil
Verapamil inhibits both CYP3A4 and P-glycoprotein, increasing colchicine plasma concentrations with risk of neuromyopathy, pancytopenia, and multi-organ toxicity.
What you should do
Reduce colchicine dose by at least 50% (or to every other day dosing) and avoid combination in patients with renal or hepatic impairment. Monitor for myopathy and blood dyscrasias.
Key facts
Severity
Major — avoid combination
Mechanism
Verapamil inhibits both CYP3A4 and P-glycoprotein, increasing colchicine plasma concentrations with risk of neuromyopath...
Action
Reduce colchicine dose by at least 50% (or to every other day dosing) and avoid combination in patients with renal or he...
Frequently asked questions
Can I take Colchicine and Verapamil together?
No — this combination should generally be avoided. Reduce colchicine dose by at least 50% (or to every other day dosing) and avoid combination in patients with renal or hepatic impairment. Monitor for myopathy and blood dyscrasias.
What is the severity of this interaction?
The interaction between Colchicine and Verapamil is classified as Major — avoid combination. Verapamil inhibits both CYP3A4 and P-glycoprotein, increasing colchicine plasma concentrations with risk of neuromyopathy, pancytopenia, and multi-organ toxicity.
What should I do if I'm prescribed both?
Reduce colchicine dose by at least 50% (or to every other day dosing) and avoid combination in patients with renal or hepatic impairment. Monitor for myopathy and blood dyscrasias. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.