Digoxin and Dronedarone: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Digoxin and Dronedarone unless specifically directed by your doctor.
How Digoxin interacts with Dronedarone
Dronedarone inhibits P-glycoprotein-mediated digoxin transport, raising digoxin plasma concentrations approximately 2.5-fold and increasing the likelihood of digitalis toxicity and bradycardia.
What you should do
Halve the digoxin dose when starting dronedarone and monitor digoxin level, renal function and ECG within one week.
Key facts
Severity
Major — avoid combination
Mechanism
Dronedarone inhibits P-glycoprotein-mediated digoxin transport, raising digoxin plasma concentrations approximately 2.5-...
Action
Halve the digoxin dose when starting dronedarone and monitor digoxin level, renal function and ECG within one week.
Frequently asked questions
Can I take Digoxin and Dronedarone together?
No — this combination should generally be avoided. Halve the digoxin dose when starting dronedarone and monitor digoxin level, renal function and ECG within one week.
What is the severity of this interaction?
The interaction between Digoxin and Dronedarone is classified as Major — avoid combination. Dronedarone inhibits P-glycoprotein-mediated digoxin transport, raising digoxin plasma concentrations approximately 2.5-fold and increasing the likelihood of digitalis toxicity and bradycardia.
What should I do if I'm prescribed both?
Halve the digoxin dose when starting dronedarone and monitor digoxin level, renal function and ECG within one week. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.