Dofetilide and Verapamil: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Dofetilide and Verapamil unless specifically directed by your doctor.
How Dofetilide interacts with Verapamil
Verapamil inhibits renal cation transport involved in dofetilide elimination, increasing dofetilide plasma concentrations. Higher exposure increases QT prolongation and torsades de pointes risk.
What you should do
Do not coadminister; select an alternative rate-control or antiarrhythmic strategy.
Key facts
Severity
Major — avoid combination
Mechanism
Verapamil inhibits renal cation transport involved in dofetilide elimination, increasing dofetilide plasma concentration...
Action
Do not coadminister; select an alternative rate-control or antiarrhythmic strategy.
Frequently asked questions
Can I take Dofetilide and Verapamil together?
No — this combination should generally be avoided. Do not coadminister; select an alternative rate-control or antiarrhythmic strategy.
What is the severity of this interaction?
The interaction between Dofetilide and Verapamil is classified as Major — avoid combination. Verapamil inhibits renal cation transport involved in dofetilide elimination, increasing dofetilide plasma concentrations. Higher exposure increases QT prolongation and torsades de pointes risk.
What should I do if I'm prescribed both?
Do not coadminister; select an alternative rate-control or antiarrhythmic strategy. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.