Moclobemide and Selegiline: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Moclobemide and Selegiline unless specifically directed by your doctor.

How Moclobemide interacts with Selegiline

Combined inhibition of MAO-A (moclobemide) and MAO-B (selegiline at higher doses) impairs metabolism of serotonin and tyramine, risking hypertensive crisis and serotonin syndrome.

What you should do

Combination is contraindicated. Maintain a 2-week washout period when switching between agents.

Key facts

Severity

Major — avoid combination

Mechanism

Combined inhibition of MAO-A (moclobemide) and MAO-B (selegiline at higher doses) impairs metabolism of serotonin and ty...

Action

Combination is contraindicated. Maintain a 2-week washout period when switching between agents.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Moclobemide and Selegiline together?

No — this combination should generally be avoided. Combination is contraindicated. Maintain a 2-week washout period when switching between agents.

What is the severity of this interaction?

The interaction between Moclobemide and Selegiline is classified as Major — avoid combination. Combined inhibition of MAO-A (moclobemide) and MAO-B (selegiline at higher doses) impairs metabolism of serotonin and tyramine, risking hypertensive crisis and serotonin syndrome.

What should I do if I'm prescribed both?

Combination is contraindicated. Maintain a 2-week washout period when switching between agents. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: May 19, 2026 by iMedic Medical Editorial Team. Our editorial process.