Moclobemide and Sertraline: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Moclobemide and Sertraline unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Moclobemide interacts with Sertraline

Combined MAO-A inhibition (moclobemide) and serotonin reuptake inhibition (sertraline) causes excessive synaptic serotonin accumulation, precipitating serotonin syndrome.

What you should do

Combination is contraindicated. Allow at least 1 week washout after moclobemide and 2 weeks (5 weeks for fluoxetine) after SSRIs before switching.

Key facts

Severity

Major — avoid combination

Mechanism

Combined MAO-A inhibition (moclobemide) and serotonin reuptake inhibition (sertraline) causes excessive synaptic seroton...

Action

Combination is contraindicated. Allow at least 1 week washout after moclobemide and 2 weeks (5 weeks for fluoxetine) aft...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Moclobemide and Sertraline together?

No — this combination should generally be avoided. Combination is contraindicated. Allow at least 1 week washout after moclobemide and 2 weeks (5 weeks for fluoxetine) after SSRIs before switching.

What is the severity of this interaction?

The interaction between Moclobemide and Sertraline is classified as Major — avoid combination. Combined MAO-A inhibition (moclobemide) and serotonin reuptake inhibition (sertraline) causes excessive synaptic serotonin accumulation, precipitating serotonin syndrome.

What should I do if I'm prescribed both?

Combination is contraindicated. Allow at least 1 week washout after moclobemide and 2 weeks (5 weeks for fluoxetine) after SSRIs before switching. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.