Moclobemide and Sumatriptan: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Moclobemide and Sumatriptan unless specifically directed by your doctor.
How Moclobemide interacts with Sumatriptan
Moclobemide inhibits MAO-A, the enzyme that metabolizes sumatriptan, doubling triptan exposure and increasing serotonergic activity with risk of serotonin syndrome.
What you should do
Contraindicated. Allow 2 weeks washout after stopping moclobemide before initiating triptans. Use NSAIDs or paracetamol for acute migraine treatment instead.
Key facts
Severity
Major — avoid combination
Mechanism
Moclobemide inhibits MAO-A, the enzyme that metabolizes sumatriptan, doubling triptan exposure and increasing serotonerg...
Action
Contraindicated. Allow 2 weeks washout after stopping moclobemide before initiating triptans. Use NSAIDs or paracetamol ...
Frequently asked questions
Can I take Moclobemide and Sumatriptan together?
No — this combination should generally be avoided. Contraindicated. Allow 2 weeks washout after stopping moclobemide before initiating triptans. Use NSAIDs or paracetamol for acute migraine treatment instead.
What is the severity of this interaction?
The interaction between Moclobemide and Sumatriptan is classified as Major — avoid combination. Moclobemide inhibits MAO-A, the enzyme that metabolizes sumatriptan, doubling triptan exposure and increasing serotonergic activity with risk of serotonin syndrome.
What should I do if I'm prescribed both?
Contraindicated. Allow 2 weeks washout after stopping moclobemide before initiating triptans. Use NSAIDs or paracetamol for acute migraine treatment instead. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.