Nitrate and Tadalafil: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Nitrate and Tadalafil unless specifically directed by your doctor.
How Nitrate interacts with Tadalafil
PDE5 inhibitors potentiate nitrate-induced increases in cyclic GMP, producing profound vasodilation and life-threatening hypotension that may persist up to 48 hours after tadalafil.
What you should do
The combination is contraindicated; nitrates must not be administered within 48 hours of tadalafil, and any nitrate-treated chest pain should be managed with non-nitrate alternatives.
Key facts
Severity
Major — avoid combination
Mechanism
PDE5 inhibitors potentiate nitrate-induced increases in cyclic GMP, producing profound vasodilation and life-threatening...
Action
The combination is contraindicated; nitrates must not be administered within 48 hours of tadalafil, and any nitrate-trea...
Frequently asked questions
Can I take Nitrate and Tadalafil together?
No — this combination should generally be avoided. The combination is contraindicated; nitrates must not be administered within 48 hours of tadalafil, and any nitrate-treated chest pain should be managed with non-nitrate alternatives.
What is the severity of this interaction?
The interaction between Nitrate and Tadalafil is classified as Major — avoid combination. PDE5 inhibitors potentiate nitrate-induced increases in cyclic GMP, producing profound vasodilation and life-threatening hypotension that may persist up to 48 hours after tadalafil.
What should I do if I'm prescribed both?
The combination is contraindicated; nitrates must not be administered within 48 hours of tadalafil, and any nitrate-treated chest pain should be managed with non-nitrate alternatives. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.