Fluoxetine and Moclobemide: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Fluoxetine and Moclobemide unless specifically directed by your doctor.
How Fluoxetine interacts with Moclobemide
Fluoxetine increases synaptic serotonin through serotonin-transporter inhibition, while moclobemide inhibits monoamine oxidase A, creating a high risk of serotonin syndrome.
What you should do
Do not coadminister. Observe the required washout period, including at least five weeks after stopping fluoxetine before starting moclobemide.
Key facts
Severity
Major — avoid combination
Mechanism
Fluoxetine increases synaptic serotonin through serotonin-transporter inhibition, while moclobemide inhibits monoamine o...
Action
Do not coadminister. Observe the required washout period, including at least five weeks after stopping fluoxetine before...
Frequently asked questions
Can I take Fluoxetine and Moclobemide together?
No — this combination should generally be avoided. Do not coadminister. Observe the required washout period, including at least five weeks after stopping fluoxetine before starting moclobemide.
What is the severity of this interaction?
The interaction between Fluoxetine and Moclobemide is classified as Major — avoid combination. Fluoxetine increases synaptic serotonin through serotonin-transporter inhibition, while moclobemide inhibits monoamine oxidase A, creating a high risk of serotonin syndrome.
What should I do if I'm prescribed both?
Do not coadminister. Observe the required washout period, including at least five weeks after stopping fluoxetine before starting moclobemide. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.